The MeBioS division of the Biosystems Department at KU Leuven investigates the interaction between biological systems and physical processes. The focus of the fundamental research in MeBioS is on the supra disciplinary field of bionanotechnology, i.e. the technology of biological systems at the nanometer scale. The Biosensors group within the division was founded in 2005 and is headed by prof. Jeroen Lammertyn. The group currently counts 6 postdocs, 23 PhD students and 3 lab technicians. Its fundamental research activities focus on the development of novel bio-molecular detection concepts and miniaturized analysis systems. The applications span a broad range of sectors including food (e.g. pathogen detection and allergenicity screening) and medical diagnostics (e.g. cancer, diabetes, infectious diseases and neurodegenerative diseases). The Biosensors group closely follows the emerging field of biosensing and is active in the following domains (1) bio-assay development (e.g. aptamers, biofunctionalized nanomaterials), (2) optical sensors (e.g. fiber optic SPR sensors) and (3) microfluidics (e.g. lab-on-a-chip technology).
For the Biosensors group (www.biosensors.be) of the Department of Biosystems at KU Leuven we are looking for a PhD student to work in the field of bionanotechnology and more specifically on the development of novel DNA nanotechnology-based strategies for continuous fiber optic biosensing.
Healthcare is in demand of technologies for continuous sensing in order to guard the state of patients, based on real-time, precise, and reliable data. Sensors for monitoring patients heart rate, muscle action, electrocardiography, temperature, blood pressure, and respiratory rate are well known. However, these sensors all rely on physical effects rather than on the underlying biomolecular processes. The ability to continuously observe biomolecular parameters such as peptides, proteins, small molecules, and nucleic acids has the potential to revolutionize health care for monitoring of disease status and treatment effect. Present-day methods and sensors for continuous monitoring are either non-specific, not sensitive enough or too slow. Therefore, novel generic biosensor technologies are needed for the continuous monitoring of biomarkers at nanomolar to picomolar concentrations, in order to observe disease status and treatment effect. This requires an interdisciplinary (molecular engineering, sensing technology, clinical applications) and intersectoral approach (academic, hospital, industry).
The CONSENSE project, funded under the Marie Sklodowska-Curie Action H2020-MSCA-ITN-2020, responds to this need by involving 9 different beneficiaries from 8 European countries and 7 partner organisations to providean excellent interdisciplinary, intersectoral and international research and training platform in the context of continuous biosensing. Through this project, a new generation of 15 innovative, entrepreneurial and creative early-stage researchers (ESRs) will be trained with knowledge/skills to become the future academic or industrial leaders in this field.
For KU Leuven, as one of the partners in this EU project, we are looking for a PhD student who will be working on the development of innovative optical biosensors based on DNA nanotechnology for continuous monitoring in biofluids. More specifically, the PhD candidate will work on a molecular nanoswitch-based fiber-optic (FO)-SPRbioassays with a focus on: 1) control over the nanoarchitecture of the bioreceptors through 2D and 3D DNA origami structures, 2) integrated aptamer-based molecular nanoswitch concepts and 3) demonstrating proof-of-concept with good stability, specificity, sensitivity and repeatability for continuous monitoring in biological fluids (e.g., serum and blood).
For more information please contact Prof. dr. ir. Jeroen Lammertyn, tel.: +32 16 32 14 59, mail: firstname.lastname@example.org or Mrs. Dragana Spasic, tel.: +32 16 37 71 18, mail: email@example.com.
You can apply for this job no later than May 31, 2021 via the online application tool
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|Intitulé||Continuous Biosensing of Biofluids with DNA Origami-based Fiber Optic Technology|
|Job location||Oude Markt 13, 3000 Leuven|
|Publié||avril 21, 2021|
|Date limite d'inscription||mai 31, 2021|
|Types d'emploi||PhD  |
|Domaines de recherche :||Optique,   Biotechnologie,   Nanotechnologie,   Biophysique,   Biologie moléculaire,   Chimie moléculaire,   Bioingénierie,   Génie des biosystèmes,   Dynamique des fluides,   |